Lödige as partner for the
pharmaceutical industry

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Pharmaceutical production worldwide is subject to the absolute highest standards regarding safety, purity and reproducibility. Our products and services are subject to these same internationally valid quality standards. In the context of these criteria, our specific processing know-how for mixing, drying, granulation and coating systems forms the basis of our innovative system solutions for the pharmaceutical industry.

The customer-oriented design of our machines and machine lines comes just as natural to us as strict adherence to all current GMP directives, FDA regulations as well as production of WIP/CIP systems. Over decades of close cooperation with the representatives of major manufacturers of pharmaceutical products our skills have been in high demand and we have proven ourselves with over 1,000 systems adapted to our customers’ specific requirements.

A test centre for pharmaceuticals, which meets the requirements of GMP-compliant series of trials and small production batches, is available at our location in Paderborn/Germany for process development and achieving a reliable scale-up to machines at a production scale. The pharmaceutical test centre is equipped with devices for mixing, wet granulation, sieving, drying and coating.

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Through its wide range of different process engineering systems and machines, Lödige provides a product-specific process design which can ensure the defined quality properties of frequently highly sensitive products. All systems listed below are available both in production sizes and in sizes suitable for Laboratory work.

Pharmaceutical machines by Lödige

Lödige provides various mixing, granulation, drying, fluid bed and coating systems for the different process engineering based production steps required for pharmaceutical products. Check the following list for an overview of the individual machines.

Coater-System (Laboratory machine)

Innovative design, great functionality Variable filling level between 0.6 and 6.0 l High process speed due to high spray rates and high drying capacity Even distribution of the suspension Process conditions comparable to Lödige production coaters User-friendly: Easy handling, intuitive operation

Coater System

Filling level variability without drum replacement The extremely low height of the mixing elements permits a high degree of filling level variability. Even application and short process times The high number of mixing elements and nozzles ensures ideal distribution and leads to low variance in the evenness of application. High-speed = Time is money The even air distribution throughout the entire drum length ensures that the drying effectiveness is high and permits high spray rates. Optimised air routing: A quality improvement This air routing prevents spray drying, increases service life for campaign production and reduces the cleaning workload. Simple cleaning A sophisticated cleaning system and its great mechanical effect make cleaning quick and efficient. This saves time, cleaning agents and energy.

Fluid bed dryer LCF for continuous operation

Lödige has years of expertise in continuous granulation. Nowadays, continuous ringlayer mixers are established systems for continuous granulation in many industries. However, until now the Lödige product range was missing a suitable dryer. The continuous fluid bed dryer closes this gap. Together with the ringlayer mixer CoriMix® and the customer-specific dosing system, this dryer provides a complete continuous granulation line: GRANUCON®. Dryer operation is based on the fluid bed process. A general disadvantage of continuous fluid beds is the wide retention time distribution within the machine. Lödige’s developers have looked into this problem and have found a solution: integrating a screw in the fluid bed dryer. This has a limiting effect on the retention time distribution.

Mixing granulator (Laboratory machine)

Laboratory mixing granulator with exchangeable vessel Mixing, granulation and temperature control in one machine Exchangeable vessels with a volume of 1, 5, 10 or 15 l GMP-compliant design User-friendly, integrated control system Operation-ready system

Ploughshare® Mixer (Laboratory machine)

Guaranteed Lödige quality Attractive value for money Functional design Ideal for your product and process development Extensive range of accessories

Ploughshare® Mixers for batch operation "Hygienic Design"

We develop customised solutions, adapted perfectly to your application and product, for any of your tasks. Extremely high mixing quality Short mixing times Reproducibility of batches Gentle product treatment High availability Low-maintenance mixer concept Easy accessibility of all internal mixer components Multi-stage processes in one machine

Ringlayer mixer CoriMix® for continuous operation

Compact machine unit with high throughput Extremely high mixing homogeneity Versatile application options Easy operation and cleaning High operating reliability and service life

The Lödige high-speed granulator

Versatile application options for the pharmaceutical and food industry GMP-compliant design Usable as a single unit or combined with a cooling mixer User-friendly control system with pre-defined process steps Many additional options available (CIP system, qualification, etc.)

The mixing granulator

Mixing granulator for pharmaceutical products, cosmetics and food GMP-compliant design Modular WIP system for the machine and all additional components Automatic liquid addition in different versions New pharmaceutical controls Temperature control jacket for heating/cooling Integrated sieve on machine outlet Vacuum feeder Customised ATEX concepts

Vacuum shovel dryer DRUVATHERM®

Intense mixing prevents temperature and moisture gradients within the product Maximum heat transfer coefficients ensure excellent dryer performance Gentle thermal product treatment in vacuum mode Multi-phase process (mixing, granulation, drying, cooling) Cost-efficient solvent recovery

Vacuum shovel dryer DRUVATHERM® (Lab machine)

Reliable scale-up Production development under consideration of industrial factors “All-in-one process” (mixing, granulation, drying, cooling) Intense mixing prevents temperature and moisture gradients within the product Short drying times through intense product movement and effective application of thermal energy Gentle thermal treatment at low temperatures using a strong vacuum Cost-efficient solvent recovery

In the past decades, Lödige has become an established partner for process engineering machines and machine lines in the pharmaceutical market at home and abroad. Global leaders from the segment of pharmaceutical companies conducting research rely on our technology just as much as producers of generic medicines, contract manufacturers and small specialised companies manufacturing niche products. The range of machines supplied by our company goes far beyond our high-quality mixing systems. Lödige mixing granulators form an important part of granulation lines of notable German and international pharmaceutical companies. As an ideal addition to our mixing granulators, our fluid bed processors, one of our most recent products, has also been employed with great success by a growing number of users.

As one of only few suppliers of the pharmaceutical industry, we can boast numerous references for continuous systems used for the production of mixes and granulated products to manufacture solid dosage forms. Continuous systems for direct compression and wet granulation are used in this context.

Our optimised coating system sets new standards for coating speed, efficiency and filling level variability.

As an option, all of our pharmaceutical machines can be equipped with WIP/CIP systems.